WHAT IF
Your agent, lender and escrow officer are experienced in working through the "what ifs"
What if the appraisal by the lender, who is making the loan for the buyers, comes in at an evaluation lower than the sale price, and the loan amount is reduced?
What if after the appraisal or the review, the lender will still not increase the loan to the amount requested by the buyer/borrowers?
What if the sale price is altered due to a low appraisal, can the sellers then re-negotiate other items in the transaction such as payment of closing costs, payment for repairs to be made and even commissions and fees to be paid to the agents, brokers and lenders?

What if the buyer, though they were pre-qualified for the loan, ultimately do not qualify for the loan?  (This can occur for a number of reasons such as loss of job, divorce, reduction of income, etc.)
What if one or more of the parties to the transaction are not completing their part of the sale efficiently and within the specified time and it appears that these actions or in-actions are going to delay the closing?
What if the seller decides not to sell after the purchase contract has been signed and the closing process has already started?
What if the termite, roof, home or other inspections result in more work than expected and the expense for these repairs in much greater than the parties anticipated?
What if the home suffers major damage or is destroyed by an earthquake, flood, hurricane, fire or some other act of nature?
What if liens and encumbrances have been placed against the property?  For example, it either party were given a large tax lien which would need to be paid out of the proceeds of the sale of the property?